INCREASED SOX2-POSITIVE CELLS IN BRAF(V600E) MUTATED AMELOBLASTOMAS
نویسندگان
چکیده
منابع مشابه
Multifocal BRAFV600E-Mutated Melanoma in situ on the Foot
Melanoma is an aggressive skin cancer that originates from melanocytes, and about one half of melanoma cases possess a BRAF mutation. Together with PD-L1 expression, the BRAF(V600E) mutation is one of the optimal therapeutic targets for the treatment of melanoma. In this report, we describe a case of multifocal melanoma in situ on the foot, which carried the p.V600E mutation in the BRAF gene. I...
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The BRAFV600E mutation, which in melanoma is targetable with vemurafenib, is also found in sarcomas and we here evaluate the therapeutic potential in sarcoma cell lines. METHODS Four sarcoma cell lines harboring the BRAFV600E mutation, representing liposarcomas (SA-4 and SW872), Ewing sarcoma (A673) and atypical synovial sarcoma (SW982), were treated with vemurafenib and the effects on cell g...
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Sporadic colorectal cancer (CRC) is a common malignancy and also one of the main causes of cancer deaths worldwide. Aberrant expression of the transcription factor SOX2 has recently been observed in several cancer types, but its role in CRC has not been fully elucidated. Here we studied the expression of SOX2 in 441 CRC patients by immunohistochemistry and related the expression to clinicopatho...
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BACKGROUND Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. OBJECTIVE AND METHODS The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-...
متن کاملCervical Cancer Cells with Positive Sox2 Expression Exhibit the Properties of Cancer Stem Cells
BACKGROUND Although Sox2 expression has been found in several types of cancer, it has not yet been used to identify or isolate CSCs in somatic carcinoma. METHODS SiHa and C33A cells stably transfected with a plasmid containing human Sox2 transcriptional elements driving the enhanced green fluorescent protein (EGFP) reporter were sorted into the Sox2-positive and the Sox2-negative populations ...
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ژورنال
عنوان ژورنال: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
سال: 2019
ISSN: 2212-4403
DOI: 10.1016/j.oooo.2019.02.105